Common core bacterial biomarkers of bladder cancer based on multiple data sets

Recent studies have shown that microorganisms can promote the onset and development of bladder cancer, but the role of microorganisms in the pathogenesis of bladder cancer remains unclear. The purpose of this study was to identify the common core bacteria associated with bladder cancer. We have characterized the urinary microbial profile of bladder cancer by 16S rRNA gene sequencing, and the results of 24 bladder cancer samples, collected in our laboratory, reveal 31 common core bacteria. In addition, the abundance of four common core bacteria is significantly higher in bladder cancer samples than in samples from non-diseased people, based on two previous data sets. In particular, the abundance of Acinetobacter is much higher in bladder cancer samples. It has been reported that Acinetobacter is involved not only in biofilm formation but also in the adhesion and invasion of epithelial cells, the spread of bacteria caused by the degradation of phospholipids in the mucosal barrier, and the escape of the host immune response. Thus, Acinetobacter may be related to bladder cancer and is a potential microbial marker of bladder cancer. However, due to the limited number of participants, further studies are needed to better understand the role of microorganisms in bladder cancer to provide novel biomarkers for diagnosis, prognosis, and therapy.