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Identification of NOTCH3 unique target genes. Identification of NOTCH3 unique target genes

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NIAID Data Ecosystem2026-03-11 收录
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Notch signaling is an evolutionarily conserved signaling pathway.NOTCH3 signaling has been shown to potentially paly an important role in luminal cell fate commitment in human breast tissue by regulating unique target genes We overexpressed the intracellular domain of NOTCH1 (N1ICD) and NOTCH3 (N3ICD) receptor in nonmalignant human breast cell line, 184-hTerts Overall design: 184-hTert cells were lentivirally transduced with either empty vector control, N1ICD or N3ICD. RNA was isolated for affymetrix microarray analysis

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2019-02-26
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