Angiogenesis and vasculogenic mimicry (VM) are thought to be the predominant processes ensuring tumor blood supply during the growth and metastasis of glioblastoma (GBM). Celastrol has potential anti-

NIAID Data Ecosystem40

Structural basis for mTORC1 regulation by the CASTOR1-GATOR2 complex

结构生物学

mTOR信号通路调控

7.77 Å cryo-EM map for GATOR2-Castor1-Sestrin2 complex and coordinates of an AlphaFold predicted model of Sestrin2 bound to one copy of WDR24, two copies of SEH1L and one copy of MIOS docked into the

Figshare2025-07-26 更新30

screen miRNAs specifically regulated by mTORC1 or mTORC2

mTOR信号通路调控

miRNA表达谱分析

To screen miRNAs specifically regulated by mTORC1 or mTORC2, a global miRNA expression profile in MCF-7 cells treated with rapamycin or PP242 (mTORC1/2 kinase inhibitor) was developed using microarray

NIAID Data Ecosystem70

Treatment with LPAAT-β siRNA results in inhibition of phosphorylation of mTOR effector proteins 4E-BP1, S6K, and AKT.

LPAAT-β基因沉默

mTOR信号通路调控

AsPC-1 (A) and MiaPaCa2 (B) cells were treated for 72 hr with 25 nM LP-1, LP-4, non-targeting siRNA (nt), or a mock transfectant (m). Western blots were done with the indicated antibodies to mTOR eff

NIAID Data Ecosystem40

Cardiac energy dependence on glucose activates metabolic genes controlled by mTOR

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