RNA-seq in IL1RA over-expressing PS19 mice
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1228838
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资源简介：
Pro-inflammatory signaling has been implicated in the pathogenesis of Alzheimer's disease (AD). Specifically, the canonical pro-inflammatory cytokine, interluekin-1, has been shown to exacerbate pathology. To investigate if disrupting interleukin-1 signaling may be a potential therapeutic in AD, Interleukin-1 receptor antagonist or GFP (control) were over-expressed via adeno-associated viral vectors in brain of 6-month old PS19 mice, a model of tauopathy. Tissue was collected at 9 months of age and total RNA was isolated from posterior cortex.
创建时间：
2025-02-26
