RNA-mediated physics, chemistry, and molecular epigenetics

Olfaction and the innate immune system link energy as information from the epigenetic landscape to the physical landscape of supercoiled DNA. The sun's biological energy is the source of the information that links angstroms to ecosystems via physics, chemistry, and molecular epigenetics.<br>RNA-mediated protein folding chemistry and amino acid substitutions link the anti-entropic quantized energy of sunlight from the virucidal effects of ultraviolet (UV) light to healthy longevity via biophysically-constrained energy-dependent hydrogen-atom transfer in DNA base pairs in solution and cell type differentiation.<br>Biomarkers link energy-dependent differences in base pairs and amino acid substitutions to biosignatures across the healthy life span. RNA-mediated amino acid substitutions also reveal the increasing complexity of interactions among cell types as pathology progresses. For comparison, successful reproduction links energy from supercoiled DNA to protection of all organized genomes from virus-driven energy theft and pathology.<br>This model links the sun's biological energy from top-down causation in microbes to the most recent model of bottom-up gene activation and cell type differentiation in vertebrates. Citations to extant literature provide examples of what is currently known about how ecological variation leads to biophysically constrained cell type differentiation in the context of nutritional epigenetics and Precision Medicine, which clearly link metabolic networks and genetic networks to pharmacogenomics.

嗅觉与先天免疫系统可将作为信息的能量，从表观遗传景观传递至超螺旋DNA的物理景观。太阳的生物能量是通过物理学、化学与分子表观遗传学，将埃尺度连接至生态系统的信息源头。
RNA介导的蛋白质折叠化学与氨基酸置换，将源自紫外线（UV）光抗病毒效应的太阳光反熵量化能量，通过溶液中受生物物理约束且依赖能量的DNA碱基对氢原子转移与细胞类型分化，关联至健康长寿。
生物标志物可将依赖能量的碱基对差异与氨基酸置换，与健康生命周期内的各类生物特征信号相连接。RNA介导的氨基酸置换还可揭示，随着病理进程发展，细胞类型间相互作用的复杂度不断提升的机制。作为对照，成功的繁殖过程可将源自超螺旋DNA的能量，与所有有序基因组免受病毒驱动的能量窃取与病理损伤的保护机制相关联。
本模型将微生物中自上而下因果关系所关联的太阳生物能量，与脊椎动物中最新的自下而上基因激活及细胞类型分化模型相连接。引用现有文献提供了当前已知的案例，阐明在营养表观遗传学与精准医学（Precision Medicine）的框架下，生态变异如何通过生物物理约束机制介导细胞类型分化；而精准医学框架已明确将代谢网络与遗传网络关联至药物基因组学研究。