ORTHORHOMBIC COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') WITH THE INHIBITOR 4'-CARBOXY-6,8-CHLORO- FLAVONOL (FLC21)

ORTHORHOMBIC COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') WITH THE INHIBITOR 4'-CARBOXY-6,8-CHLORO- FLAVONOL (FLC21) Descriptor: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, ACETATE ION, CHLORIDE ION, ... Authors: Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O. Deposit date: 2016-10-19 Release date: 2017-01-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.195 Å) Cite: Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor. Pharmaceuticals, 10, 2017

人蛋白激酶CK2（Protein Kinase CK2）催化亚基（CK2α'亚型）与抑制剂4'-羧基-6,8-二氯黄酮醇（FLC21）的正交晶系复合物结构
描述项：4-[6,8-二(氯原子)-3-羟基-4-氧代色烯-2-基]苯甲酸、乙酸根离子、氯离子……
作者：Niefind, K、Bischoff, N、Yarmoluk, S.M、Bdzhola, V.G、Golub, A.G、Balanda, A.O、Prykhod'ko, A.O
保藏日期：2016-10-19
发布日期：2017-01-18
最后修改日期：2024-01-17
实验方法：X射线衍射（分辨率2.195 Å）
引用文献：《两种人蛋白激酶CK2催化亚基旁系同源体的结构超变异性——基于黄酮醇与噻吩并[2,3-d]嘧啶类抑制剂的复合结构解析》，发表于《Pharmaceuticals》2017年第10卷。