Crystal structure of the second bromodomain (BD2) of human BRDT bound to ERK5-IN-1

Crystal structure of the second bromodomain (BD2) of human BRDT bound to ERK5-IN-1 Descriptor: 1,2-ETHANEDIOL, 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain testis-specific protein, ... Authors: Chan, A, Karim, M.R, Schonbrunn, E. Deposit date: 2021-01-14 Release date: 2021-07-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64, 2021

人类BRDT的第二个溴结构域（bromodomain，BD2）与ERK5-IN-1结合的晶体结构。描述项：1,2-乙二醇，11-环戊基-2-({2-乙氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-羰基]苯基}氨基)-5-甲基-5,11-二氢-6H-嘧啶并[4,5-b][1,4]苯并二氮杂䓬-6-酮，睾丸特异性溴结构域蛋白（Bromodomain testis-specific protein）等。作者：Chan, A、Karim, M.R、Schonbrunn, E。存档日期：2021-01-14，发布日期：2021-07-14，最后修改日期：2023-10-18。实验方法：X射线衍射（2.75 Å）。引用文献：《二氢蝶啶酮与嘧啶并二氮杂䓬酮类激酶抑制剂对BET溴结构域的差异化抑制作用（Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors）》，J.Med.Chem.，第64卷，2021年。