Genomic profiling of gastric carcinoma in situ by array-based comparative genomic hybridization (CBX95). unidentified

Although genomic copy number aberrations (CNAs) of gastric carcinoma in advanced stage have already been characterized by many array comparative genomic hybridization (array CGH) analyses, those of gastric carcinoma in situ (CIS) have been poorly understood. In this study, we investigated CNAs of 20 gastric CIS by oligonucleotide-based array CGH. The most frequent aberrations in CIS were gains at 8q (85%) and 20q (50%), and losses at 5q (50%) and 17p (50%), suggesting that these CNAs may be involved in the development of CIS.