Asymmetric Catalytic Enantio- and Diastereoselective Boron Conjugate Addition Reactions of α‑Functionalized α,β-Unsaturated Carbonyl Substrates

An efficient catalytic system has been established for the asymmetric boron conjugate addition of B2pin2 onto α-functionalized (involving C, N, O, and Cl) α,β-unsaturated carbonyls under mild, neutral conditions involving Cu­[(S)-(R)-ppfa]­Cl, AgNTf2, and alcohols. The dual additives of AgNTf2 and alcohols were found to play crucial roles for achieving high catalytic activity and enantio- and diastereoselectivity (up to 98% ee and 70:1 dr).