The Synthesis of Certain Derivatives and Analogues of (−)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase

Syntheses
of certain di- and mono-oxygenated derivatives (e.g., 2 and 3, respectively) and analogues (e.g., 4, a D-ring monoseco-analogue of 2) of both the
(−)- and (+)-enantiomeric forms of the alkaloid galanthamine
[(−)-1] are reported. All have been assessed for
their capacities to inhibit acetylcholine esterase but, in contrast
to the predictions from docking studies, none bind strongly to this
enzyme.