Enrichment of functionally related genes in groups of co-expressed genes.

8/15 clusters were identified to contain cohorts of functional related genes (p<0.05; >2-fold enrichment) primarily represented by transcription factors (clustes 1/2/5/12) and genes associated with limb/skeletal morphogenesis (clusters 1/2/5/6). ‘Gene count’ represents the number of genes in the cluster with the specified biological process or molecular function, while ‘total # genes’ represents the total number of genes present on the microarray within the same category. Enrichment is fold over background. Genes corresponding to GO enriched categories highlighted in brown are plotted in Figure 5. BP biological process; MF molecular function.