Supplemental Materials to submitted paper

This file contains the supplemental materials to the paper: <em>Esteban O. et al., Surface-driven registration method for the structure-informed segmentation of diffusion MR images. NeuroImage (accepted), 2016. </em><em>doi: http://dx.doi.org/10.1016/j.neuroimage.2016.05.011</em><em><br></em> <strong>Abstract:</strong> Current methods for processing diffusion MRI (dMRI) to map the connectivity of the human brain require precise delineations of anatomical structures. This requirement has been approached either segmenting the data in native dMRI space or mapping the structural information from T1-weighted (T1w) images. The characteristic features of diffusion data in terms of signal-to-noise ratio, resolution, as well as the geometrical distortions caused by the inhomogeneity of magnetic susceptibility across tissues hinder both solutions. Unifying the two approaches, we propose regseg, a surface-to-volume nonlinear registration method that segments homogeneous regions within multivariate images by mapping a set of nested reference-surfaces. Accurate surfaces are extracted from a T1w image of the subject, using as target image the bivariate volume comprehending the fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) maps derived from the dMRI dataset. We first verify the accuracy of regseg on a general context using digital phantoms. Then we establish an evaluation framework using undistorted dMRI data from the Human Connectome Project (HCP) and known deformations derived from real inhomogeneity fieldmaps. We analyze the performance of regseg computing the misregistration error of the surfaces estimated after being mapped with regseg onto 16 datasets from the HCP. The distribution of errors shows a 95% CI of 0.56–0.66 mm, that is below the dMRI resolution (1.25 mm, isotropic). Finally, we cross-compare the proposed tool against a nonlinear b0-to-T2w registration method, thereby obtaining a significantly lower misregistration error with<br>regseg. Therefore, we demonstrate that regseg allows the accurate mapping of structural information in dMRI space, enabling the application of new structure-informed techniques in the connectome extraction.