TBC1D16 accelerates GTP hydrolysis by RAB4A

RAB4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. It is involved in transferrin receptor recycling and EGFR trafficking and signalling. TBC (Tre2/Bub2/Cdc16) domain family member 16 (TBC1D16), is a GTPase activating protein for Rab4A and enhances the intrinsic rate of GTP hydrolysis by RAB4A (Goueli et al. 2012).

RAB4A 作为内吞小室至质膜受体回收过程的调控大师，其在转铁蛋白受体回收以及EGFR的运输和信号转导中发挥着重要作用。TBC（Tre2/Bub2/Cdc16）结构域家族成员16（TBC1D16），作为Rab4A的GTP酶激活蛋白，能显著提升RAB4A的内源性GTP水解速率（Goueli等，2012年）。