dog-PKCV-data

Pharmacokinetic and pharmacodynamic data for five reference compounds (verapamil, captopril, dofetilide, pimobendan and formoterol) affecting the dog cardiovascular system These files accompany the article 'An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds' by Mikael Wallman, Jens Markus Borghardt, Eric Martel, Nicolas Pairet, Michael Markert, and Mats Jirstrand submitted for publication to the Journal of Pharmacological and Toxicological Methods This description will be updated with a permanent link to the manuscript upon publication. Files: dog_all_compounds.xlsx - cardiovascular telemetry readouts (hear rate, mean arterial pressure and QT-interval) from inhalational (formoterol) and oral (verapamil, captopril, dofetilide, pimobendan) dosing obtained in Labrador dogs by Boehringer-Ingelheim Pharma & Co KG during trials with the five reference compounds. dog_all_compounds_PK.xlsx - digitized pharmacokinetic data from intravenous (all), intratracheal (formoterol), and oral (verapamil, captopril, dofetilide, pimobendan) dosing in dog, with source publications indicated in the file. VPC and sVPC plots.pdf - supplementary validation plots for the dog cardiovascular model described in the article above