Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Here we report that Axitinib, an inhibitor of VEGFRs currently in use as a second line treatment for advanced renal cell carcinoma, promotes senescence of human endothelial cells in vitro. Mechanistically, this requires oxidative stress-dependent activation of the Ataxia Telangiectasia Mutated (ATM) kinase. Induction of oxidative stress-related genes distinguishes the response of endothelial cells to Axitinib from that to doxorubicin
提供机构：
University of Bologna
创建时间：
2022-02-20
