2'-5' Oligoadenylate Synthetase-Like 1- (OASL1-) deficient mice promote antiviral protection against Pseudorabies Virus Infection through robust production of type I interferons

Figure 1. Upregulation of OASL1 following PRV infection, observed both in vivo and in vitro.
Figure 2. Enhanced resistance to PRV and reduced viral burden in Oasl1-/- mice.
Figure 3. Effects of Oasl1-/- on pro-inflammatory mediators in PRV infection as determined by qRT-PCR.
Figure 4. Oasl1-/- mice exhibit reduced inflammation following PRV infection.
Figure 5. Oasl1−/− mice exhibit less severe pathological alterations following PRV infection.
Figure 6. Increased Type I IFN Secretion via IRF7 Signaling in PRV-infected Oasl1⁻/⁻ Mice.
Figure 7. OASL1-ablated myeloid-derived cells produce elevated levels of type I IFNs after PRV infection.