Clathrin-mediated endocytosis in viral entry

Figure 1.. Following attachment, viruses bind to cellular receptors and activate signaling pathways involving receptor tyrosine kinases (depicted in the lavender box) to promote internalization of the receptor?virus complex via the route of the specific receptor. This process is dependent on clathrin, clathrin adaptors (shown in the green box), and actin and microtubule dynamics proteins (shown in yellow box), and is tightly regulated. Viral particles are then transported by clathrin-coated vesicles to various endosomal compartments for uncoating of the viral genome and its penetration into the cytoplasm. Depicted are different endosomal compartments, specific host factors (blue panel), and examples of viruses utilizing them for penetration (maroon panel).