Transcriptome of <em>Peromyscus leucopus</em> brain and lungs infected with SARS-CoV-2

This dataset contains RNA sequencing (RNA-seq) data generated from brain and lung tissues of Peromyscus leucopus. Animals were either experimentally infected with SARS-CoV-2 or exposed to medium as controls. The study was designed to characterize the transcriptional response of lung and brain tissue to viral infection and to identify differentially expressed genes associated with this response. Tissue samples were collected at day 3 and day 6 post-infection. Total RNA was extracted, and sequencing libraries were prepared and subjected to high-throughput sequencing. Raw sequencing reads were processed and aligned to the reference P. leucopus coding DNA sequence (CDS) dataset (DOI: 10.5061/dryad.hdr7sqvwr). Gene expression levels were quantified and normalized, producing Transcripts Per Million (TPM) values or Unique Gene Reads (UGR) for each gene. , , # Transcriptome of *Peromyscus leucopus* brain and lungs infected with SARS-CoV-2 GENERAL INFORMATION 1\. Title of Dataset: Transcriptome of Peromyscus leucopus brain and lungs infected with SARS-CoV-2 2\. Author Information  A. Principal Investigator Contact Information  Name: Alan G. Barbour  Institution: University of California Irvine <br />  Address: 843 Health Sciences Court, Irvine, CA 92697  Email: [[e-mail]](mailto:[e-mail])  B. Associate or Co-investigator Contact Information  Name: Ana Milovic  Institution: University of California Irvine  Address: 843 Health Sciences Court, Irvine, CA 92697  Email: [[e-mail]](mailto:[e-mail]) 3\. Date of data collection (single date, range, approximate date): 2020-2022 4\. Geographic location of data collection: Irvine, California, USA 5\. Information about funding sources that supported the collection of the data: National Institute of Allergy and Infect..., ,