Association of replication origins with chromatin states and timing.

Origins associated with a given chromatin state (in percent) correspond to origins that overlap with published chromatin state coordinates [22], from the UCSC Genome Browser with chromHMM 1: active promoter, chromHMM 2: weak promoter, chromHMM 3: inactive/poised promoter, chromHMM 4: strong enhancer, chromHMM 5: strong enhancer, chromHMM 6: weak/poised enhancer, chromHMM 7: weak/poised enhancer, chromHMM 8: insulator, chromHMM 9: transcriptional transition, chromHMM 10: transcriptional elongation, chromHMM 11: weak transcribed, chromHMM 12: Polycomb-repressed, chromHMM 13: heterochromatin; low signal, chromHMM 14: repetitive/copy number variation, chromHMM 15: repetitive/copy number variation. The expected (Exp.) percentage and significance of association ( for significant enrichment, with and for significant depletion) were calculated with random genomic segments sampled from mappable regions (see Materials and Methods).