BRCA Mutation Status Shapes the Microenvironment of Pancreatic Adenocarcinoma

This study was established in order to address how the stromal landscape is influenced by BRCA-mutated and BRCA Wild-type (WT) pancreatic ductal adenocarcinoma (PDAC). A primary cohort of 12 PDAC patients (7 BRCA-WT and 5 germline BRCA-mut) was analyzed by laser-capture microdissection, RNA-sequencing and multiplexed immunofluorescence. ]]>
Only patients with germline mutations in BRCA1/2 were included as “BRCA-mut patients”, and only patients with no known germline or somatic mutations in BRCA1/2 were included as “BRCA-WT patients”. ]]>