Structure of Kluyveromyces lactis mRNA cap (guanine-N7) methyltransferase, Abd1, in complex with sinefungin

Structure of Kluyveromyces lactis mRNA cap (guanine-N7) methyltransferase, Abd1, in complex with sinefungin Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... Authors: Nilson, D.J, Fedorov, E, Ghosh, A. Deposit date: 2024-12-10 Release date: 2025-07-09 Last modified: 2025-08-06 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic sinefungin. Nucleic Acids Res., 53, 2025

乳酸克鲁维酵母（Kluyveromyces lactis）mRNA帽（guanine-N7）甲基转移酶Abd1与正弦菌素（sinefungin）复合物的晶体结构。结晶试剂：1,2-乙二醇、2-氨基-2-羟甲基-1,3-丙二醇、二(羟乙基)醚等……作者：Nilson D.J.、Fedorov E.、Ghosh A.。沉积日期：2024-12-10；发布日期：2025-07-09；最后修改日期：2025-08-06。解析方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.59埃。引用文献：《真菌帽状结构鸟嘌呤-N7甲基转移酶对抗真菌抗生素正弦菌素的敏感性与获得性耐药的结构基础》，《核酸研究（Nucleic Acids Res.）》，2025年，第53卷。