Table_1_Anthropometric Measures and Incident Diabetic Nephropathy in Participants With Type 2 Diabetes Mellitus.docx

BackgroundThe prevalence of diabetes is on the rise globally coupled with its associated complications, such as diabetic nephropathy (DN). Obesity has been identified as a risk factor for the development of DN but it is still unclear which obesity index is the best predictor of incident DN.MethodsData from the participants with type 2 diabetes mellitus (T2DM) in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study were used to examine the sex-specific association between waist circumference (WC), waist-to-height ratio (WHtR), and body mass index (BMI) with incident DN risk.ResultsAmong the 8,887 participants with T2DM (5,489 men and 3,398 women), 5,296 participants (3,345 men and 1,951 women) developed the DN composite outcome during a follow-up period of 24302 person-years. Among men, null associations were observed between all anthropometric measures with incident DN in the multivariate analysis although the 3rd quartile of WHtR showed marginally significant results (P = 0.052). However, among women, both central and general obesity measures were associated with increased risks of incident DN. Compared with participants in the WC

背景：全球范围内，糖尿病的发病率呈上升趋势，其相关并发症，如糖尿病肾病（DN），亦随之增多。肥胖已被确认为DN发病的风险因素，但尚不清楚哪种肥胖指标是预测新发DN的最佳指标。方法：本研究利用来自行动控制糖尿病心血管风险（ACCORD）研究中2型糖尿病（T2DM）患者的数据，探究腰围（WC）、腰高比（WHtR）和体质指数（BMI）与DN发病风险的性别特异性关联。结果：在8,887名T2DM患者（男性5,489名，女性3,398名）中，5,296名患者（男性3,345名，女性1,951名）在24302人年的随访期间出现了DN复合终点。在多因素分析中，男性各身体测量指标与DN发病之间未见显著关联，尽管WHtR的第三四分位数表现出边缘性显著结果（P = 0.052）。然而，在女性中，中心性肥胖和一般性肥胖指标均与DN发病风险增加相关。与腰围（WC）