Complement activation by beta-amyloid in Alzheimer disease.
收藏PubMed Central1992-11-01 更新2026-05-16 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC50268/
下载链接
链接失效反馈官方服务：
资源简介：
Alzheimer disease (AD) is characterized by excessive deposition of the beta-amyloid peptide (beta-AP) in the central nervous system. Although several lines of evidence suggest that beta-AP is neurotoxic, a mechanism for beta-AP toxicity in AD brain remains unclear. In this paper we provide both direct in vitro evidence that beta-AP can bind and activate the classical complement cytolytic pathway in the absence of antibody and indirect in situ evidence that such actions occur in the AD brain in association with areas of AD pathology. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-11-01
