Gene expression profiles of normal and tumor tissues from denervated prostate and intact prostate .

The phenotype and genotype of the tumors that arise in denervated prostates is not a measure of the effects of denervation on established tumors. Rather, it is a measure of their ability to escape the regulatory influence of the neural microenvironment and hence develop a resistance phenotype to denervation. This applies to human prostate cancer that arose in prostates with spinal cord injury. Our results indicate that tumors arising in denervated prostates have a significantly altered gene profile as compared to tumors arising in intact prostates. Gene expression profiles of normal and tumor tissues from denervated prostate and intact prostate (four groups, N=1 for each). All profiles were compare to the noncancer, intact prostate profile.