EvolclustDB

EvolClustDB is a public and browsable database of evolutionarily conserved gene clusters pre-computed with the EvolClust algorithm (Marcet-Houben M and Gabaldón T (2020)). This algorithm identifies groups of neighboring genes whose proximity is significantly conserved across evolution compared to the genome average. This prediction is performed pairwise in an all against all comparisons of the genomes of interest, and then predicted gene clusters are grouped into multi-species families based on shared homologous gene content. Visualization allows inspecting gene order per species in a phylogenetic context (species or taxonomy tree), enabling inference of potential evolutionary events. EvolclustDB provides gene cluster visualization through the PhyD3EvolClustDB是一款公开可浏览的进化保守基因簇数据库，所有基因簇均通过EvolClust算法（Marcet-Houben M与Gabaldón T，2020）预先计算得到。该算法可识别相较于基因组平均水平，其邻接关系在进化历程中显著保守的相邻基因群。该预测通过对目标基因组开展全对全两两比对得以完成，随后基于共享的同源基因组成，将预测得到的基因簇归类为多物种家族。其可视化功能支持在系统发育背景（物种树或分类学树）下检视各物种的基因排列顺序，进而可推断潜在的进化事件。EvolClustDB通过PhyD3提供基因簇可视化功能。

搜集汇总

背景与挑战

背景概述

EvolClustDB是一个公开可浏览的数据库，基于EvolClust算法预计算进化保守的基因簇，该算法通过基因组成对比较识别邻近性显著保守的基因群组。数据库提供基因簇可视化功能，支持在系统发育背景下分析基因顺序以推断潜在进化事件。