CeO₂ Clusterzymes: Biomimetic Synthesis and Treatment for Acute Liver Injury

Acetaminophen (APAP) overdose is a common cause of acute liver injury (ALI) in clinical settings, characterized by accumulation of reactive oxygen species (ROS) and infiltration of inflammatory cells. In this study, CeO2 clusterzymes (named as CeCs) with ultra-small size (around 1.3 nm) was synthesized by a biomimetic mineralization process. The obtained CeCs presented a high oxygen vacancy content (52.6%) and a high Ce3+/Ce4+ ratio (1.06), showing excellent adsorption and removal abilities to various ROS (including free radicals), which could be used for hepatocyte protection. In vivo animal experiments further confirmed that CeCs provided highly effective therapeutic intervention for APAP-induced ALI, extending the therapeutic window, and reversing sterile inflammation, underscoring their potential for clinical application.