Spectravax reference data: HLA alleles, haplotype frequencies, and human proteome

Reference data files required to run the Spectravax vaccine design pipeline (https://github.com/PhilPalmer/Spectravax). Files: human_proteome.fasta.gz — Human reference proteome from UniProt (downloaded 14 March 2023), used for self-peptide filtering. mhc1_alleles.txt — MHC class I allele list used for binding predictions. mhc2_alleles.txt — MHC class II allele list used for binding predictions. hap_freq_mhc1.pkl — MHC class I haplotype frequency data (pickle format). hap_freq_mhc2.pkl — MHC class II haplotype frequency data (pickle format). The haplotype frequency and allele files are derived from the dataset published by Liu et al. (2020), available at https://doi.org/10.17632/cfxkfy9zp4.1 (CC BY 4.0). Please cite: Liu, G. et al. "Computationally optimized SARS-CoV-2 MHC class I and II vaccine formulations predicted to target human haplotype distributions." Cell Systems (2020). https://doi.org/10.1016/j.cels.2020.06.009 The human proteome is from UniProt (CC BY 4.0).