Studies included in the systematic review and in the meta-analysis.

(*) Studies included in the meta-analysis (N = 19).AQAMA-PCR: Absolute Quantitative Assessment Of Methylated Alleles PCR, COBRA LINE-1: Combined Bisulfite Restriction Analysis LINE-1, COMPARE: Combination Of Methylated DNA Precipitation And Restriction Enzyme digestion, CRC: Colorectal Cancer, FCCX: Familial Colorectal Cancer type X, FLC: Fibrolamellar Carcinoma, GIST: Gastrointestinal Stromal Tumors, LINE-1: Long Interspersed Nucleotide Element 1, MSI: MicroSatellite Instable, MS-MLPA: Methylation-Specific Multiplex Ligation-dependent Probe Amplification, MSS: MicroSatellite Stable, QUBRA: Quantitative Bisulfite Restriction Analysis.Studies included in the systematic review and in the meta-analysis.