Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model

To investigate the role of HHEX in regulating human pancreatic endoderm differentiation, we knocked down the HHEX gene in 585A1 cell line-derived pancreatic endoderm cells by siRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of the 3 cell samples. Comparative gene expression profiling analysis of RNA-seq data for 585A1 cell line-derived posterior foregut cells and pancreatic endoderm cells (siHHEX and siControl).