Adipocyte thyroid hormone receptor ß determines the intracellular usage and fate of glucose and governs systemic homeostasis

To investigate the effect of thyroid hormone and its receptor on glucose and lipid metabolism in white adipose tissue (WAT), and the effect of thyroid hormone and its receptor on WAT regulation on glucose metabolism and obesity. We constructed mice with adipose tissue-specific knockout of thyroid hormone receptor beta(ATRßKO mice). ATRßKO mice were given T3 stimulation or high-fat feeding. We then performed gene expression profiling analysis using data obtained from RNA-seq of White adipose tissue from knockout ATRßKO mice treated with T3 or HFD feeding. Overall design: Comparative gene expression profiling analysis of RNA-seq data for Floxed (Veh) , Floxed (T3) and ATRßKO (T3),and for Floxed (HFD) with ATRßKO (HFD)