Additional file 1 of MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment

Additional file 1: Additional Fig. 1: Gene expression in neuroblastoma tumors and cell lines. The figure includes correlation study and survival analysis from NB patient datasets and flow cytometry analysis from neuroblastoma cell lines. Additional Fig. 2: Validation of in vitro hypoxia cytometry. Additional Fig. 3: Effect of human recombinant MIF and siCXCR4 in neuroblastoma cell lines. Additional Fig. 4: Membrane CD74 levels by flow cytometry. Additional Fig. 5: Flow cytometry density plots of 4-IPP activity. Additional Fig. 6: LAN-1 viability exposed to CM-NB, CM-BM and treated with AMD-3100 and 4-IPP. LAN-1 response to chemotherapeutic agents when exposed to CM-CNT and treated with 4-IPP. Additional Table 1: Bone marrow samples. Additional Table 2: Primer list, and Additional Table 3: Antibody list.