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Access to 27-Nortomatidine and 27-Norsoladulcidine Derivatives

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Figshare2019-03-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Access_to_27-Nortomatidine_and_27-Norsoladulcidine_Derivatives/7868372
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Synthesis of (22R)- and (22S)-27-norspirosolane alkaloids from tigogenin, epismilagenin, and smilagenin is described. The alkaloids were prepared from readily available dinorcholanic lactones via their reaction with 4-chlorobutyllithium followed by substitution of chloride with azide and reductive N-cyclization under the Staudinger conditions.
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2019-03-20
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