A Small Molecule Activator of the TET2 Tumor Suppressor. A Small Molecule Activator of the TET2 Tumor Suppressor
收藏NIAID Data Ecosystem2026-03-10 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA497516
下载链接
链接失效反馈官方服务：
资源简介：
TET2 protein is a dioxygenase that oxidizes 5-methylcytosine and is responsible for DNA demethylation. We found that a small molecule drug (3FM-dC) activates the enzyme activity of TET2. The sequencing data suggest that 3FM-dC induced global changes in DNA hydroxymethylation and gene expression. Overall design: To determine the effects of 3FM-dC on global gene expression, we performed RNA-seq on control and 3FM-dC treated K-562 cells.
创建时间：
2018-10-19
