CRISPR and biochemical screens Identify MAZ as a co-factor in CTCF-mediated insulation at Hox Clusters [ChIP-seq_set6]

In this experiment, we sought to identify how the distribution of CTCF and MAZ change in WT and MAZ knock-out (KO) cells during differentiation of mouse embryonic stem cells (ESCs) into cervical motor neurons (MNs) Overall design: Examination of CTCF and MAZ binding in embryonic stem cells and cervical motor neurons using ChIP-seq, by knock-out status of MAZ