Nitrite ion and HNO2 form a conjugated acid-base pair

In the acidic conditions nitrite (NO2-) and nitrous acid (HNO2) present as a conjugated acid-base pair. HNO2 can further react with an additional HNO2 to produce N2O3 (Oldreive C & Rice-Evans C. 2001). N2O3 formation regulates the function of many target proteins through the coupling of a nitroso moiety (NO+) to a reactive cysteine, ultimately leading to the formation of RSNO, a process commonly known as S-nitrosylation (Broniowska KA & Hogg N 2012).

在酸性条件下，亚硝酸（NO2-）和亚硝酸（HNO2）以共轭酸碱对的形式存在。HNO2可以进一步与另一分子HNO2反应，生成三氧化二氮（N2O3，Oldreive C & Rice-Evans C. 2001）。N2O3的形成通过将亚硝基团（NO+）与活性半胱氨酸偶联，从而调节众多目标蛋白的功能，最终导致S-硝基化（RSNO）的形成，这一过程通常被称为S-硝基化作用（Broniowska KA & Hogg N 2012）。