Associations between SNPs and adult height, peak height velocity in infancy (PHV1) and puberty (PHV2) and age at PHV2.

All analyses are adjusted for sex and principal components. Results are sorted by effect sizes: ten largest for PHV1 at the top followed by remaining of ten largest for PHV2 and age at PHV2, followed by the remaining SNPs in arbitrary order. The SNPs with associations at p<0.05 significance level are highlighted for adult height, PHV1 and PHV2. Beta is expressed as the change in PHV in infancy and puberty [%], and as the change in age at PHV2 [year] per one adult height increasing allele.
1Height increasing allele identified in GWAS (using the HapMap B35 + strand as the reference strand). The sign of adult height beta shows if the direction of effect was the same as in the three GWAS (+ = same, − = different).
2Interaction p-value between SNP and age (puberty vs. infancy) on PHV, values at p<0.05 level are highlighted in italics and values at p<0.01 level in bold.
3Genes with more than one SNP or SNPs close together in different genes. R2 between SNPs: LCORL 0.03, SH3GL3/ADAMTSL3 0.12, RDBP, (LST1) NCR3/AIF1/RDBP/BAT3 0.06 (all SNPs counted as separate signals); CDK6 r2 0.32–0.78, TRIP11/FBLN5 r2 0.72 and GPR126 r2 0.97 (counted as one signal per gene).