Efficacy of GDC-0941 and PD 0325901 in mice bearing human colorectal tumour xenografts.
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± standard deviation (SD) and the median RTV3 or RTV4 for each group (± interquartile range (IR)). Time taken in days for HCT116 and HT29 tumour xenografts to reach three or four times their initial volume (time to RTV3 or RTV4) when treated with either vehicle control, 1 mg/kg PD 0325901 and 100 mg/kg GDC-0941 alone, or 1 mg/kg PD 0325901 and 100 mg/kg GDC-0941 in combination, p.o. once daily for 14 days. Data are presented as the mean time to RTV3 or RTV4 for the mice in each group
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2015-12-02



