Trisubstituted 2‑Trifluoromethyl Pyrrolidines via Catalytic Asymmetric Michael Addition/Reductive Cyclization
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https://figshare.com/articles/dataset/Trisubstituted_2_Trifluoromethyl_Pyrrolidines_via_Catalytic_Asymmetric_Michael_Addition_Reductive_Cyclization/2032560
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资源简介：
The
stereoselective synthesis of trisubstituted 2-trifluoromethyl
pyrrolidines by asymmetric Michael addition/hydrogenative cyclization
is described. The direct organocatalytic addition of 1,1,1-trifluoromethylketones
to nitroolefins proceeds under mild reaction conditions and low catalyst
loadings to provide Michael adducts in high yield with excellent diastereo-
and enantioselectivity. Catalytic hydrogenation of the Michael adducts
stereoselectively generates 2-trifluoromethylated pyrrolidines
bearing three contiguous stereocenters. A stereospecific route to
epimeric 2-trifluoromethyl pyrrolidines from a common
intermediate is described.
创建时间：
2015-12-17
