Transcriptional profiling of cadmium effect in human adipocytes. Transcriptional profiling of cadmium effect in human adipocytes

Adipose tissue is a potential site of accumulation of toxicants, including trace elements, which can have an impact on tissue functionality. To investigate the molecular perturbations induced by Cd in mature adipocytes, we treated Adipose Tissue-derived human mesenchymal stem cells (AD-hMSCs) with 1microM cadmium for 48h and we used microarrays to detail the global program of gene expression. Overall design: We examined 2 experimental groups: control cells (C) and cadmium treated cells (Cd). For each experimental group we analysed the transcriptional profile of 3 biological replicates.