Wound healing mechanisms in pathogenesis control in natural SIV host species [monocytes]

We devised a systems biology approach to investigate the early host response to high-dose rectal SIV transmission, by transcriptomic comparative analysis of a natural reservoir host SIV model species, African green monkeys (AGMs – Chlorocebus sabaeus, N=28) and a pathogenic model, rhesus macaques (RMs - Macaca mulatta, N=24).on rectal tissues for both AGMs and RMs. Overall design: To investigate if AGM macrophages have a stronger wound healing profile compared to RM, we carried out mRNA sequencing on sorted M1 and M2 monocytes. Specifically, longitudinal blood samples were taken at D7, D14 and D28 post inoculation from two AGMs and four RMs