BIOGRID CURATED DATA FOR LET-756 (Caenorhabditis elegans)

Protein-Protein, Genetic, and Chemical Interactions for LET-756 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development; LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae; with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells; homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development.

由 BioGRID (https://thebiogrid.org) 精心整理的关于 LET-756（秀丽隐杆线虫 Caenorhabditis elegans）的蛋白质-蛋白质、遗传以及化学相互作用数据集；定义：let-756 编码一种类似成纤维细胞生长因子（FGF）的配体，该配体对于幼虫早期发育阶段的进展至关重要；LET-756 从胚胎晚期直至成年期均有表达，其中幼虫期的表达量达到顶峰；与 EGL-17 相互作用时，LET-756 作为冗余因子，对于激活 EGL-15/FGFR 是必需的，而 EGL-15/FGFR 又进而激活成年肌肉细胞中的蛋白质降解；部分功能丧失等位基因的纯合子个体体型微小、清晰且瘦弱，但仍能存活，而纯合子无功能等位基因的个体则会在幼虫早期发育阶段停滞。