In vivo protection of AG129 mice from West Pac-74 (genotype 4) after prophylaxis with neutralizing anti-DENV-1 MAbs.

Mice were administered with 500 µg of indicated MAbs one day before infection with 106 PFU of West Pac-74 by an IP route. Mice were monitored for survival for 60 days after infection. NS, not statistically different from PBS control.
aMean time to death (MTD) ± standard deviations (SD) refers to the mean time to death of the animals that succumbed to fatal infection. NA, indicates that no animals died in the presence of this MAb, and thus, the value was not calculated.
bP values were calculated using the log rank test of the Kaplan Meier survival curve by comparing the no antibody treated and antibody treated mice.