Data_Sheet_1_β-D-Galactose-Functionalized Pillar[5]arene With Interesting Planar-Chirality for Constructing Chiral Nanoparticles.PDF

Planar-chiral pillar[5]arenes bearing β-D-galactose substituents on both rims have been successfully synthesized and effectively separated by silica gel chromatography with a high yield. The obtained (Sp)- and (Rp)-β-D-galactose functionalized pillar[5]arenes [(Sp-D)-GP5 and (Rp-D)-GP5] exhibit the Sp and Rp planar chirality. Furthermore, (Sp-D)-GP5 and (Rp-D)-GP5 can not racemize according to dynamic 1H NMR and CD spectra. Notably, GP5 is able to capture a guest molecule (DNS-CPT) to form a host-guest supramolecular amphiphile, which can further self-assemble into chiral nanoparticles with the Sp and Rp planar chirality of (Sp-D)-GP5 and (Rp-D)-GP5 still being retained, suggesting GP5 could be as reliable chiral sources to transfer the Sp and Rp planar chirality.