Dynamics of m6A RNA methylome during leukemogenesis reveals a role of PRMT6-MFSD2A signaling axis in maintaining AML stem cells.[Chip-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE218609
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We delineate a comprehensive m6A landscape during acute myeloid leukemia (AML) development, and identify PRMT6, regulated by IGF2BP2, acting as a key for leukemia stem cell maintenance by restraining MFSD2A expression and docosahexaenoic acid level. H3R2me2a ChIP-seq of Prmt6-/- and Igf2bp2-/- leukemia cells
创建时间:
2023-12-05



