Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with JMC31

Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with JMC31 Descriptor: 1-[2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-5-[4-[(cyclohexylmethylamino)methyl]phenyl]-~{N}-ethyl-1,2,3-triazole-4-carboxamide, Heat shock protein HSP 90-alpha Authors: Tassone, G, Pozzi, C, Mazzorana, M, Mangani, S, Maramai, S. Deposit date: 2022-07-20 Release date: 2022-09-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor. Int J Mol Sci, 23, 2022

人热休克蛋白90-α N端结构域（Heat shock protein 90-alpha N-terminal domain, Hsp90-NTD）变体K112A与JMC31复合物的结构。JMC31标识符：1-[2,4-二羟基-5-异丙基苯基]-5-[4-[(环己基甲氨基)甲基]苯基]-~N-乙基-1,2,3-三唑-4-甲酰胺。作者：Tassone, G、Pozzi, C、Mazzorana, M、Mangani, S、Maramai, S。提交日期：2022-07-20；发布日期：2022-09-07；最后修改日期：2024-01-31。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.32埃（Å）。引用文献：《人热休克蛋白90 N端结构域及其变体K112R与K112A结合强效1,2,3-三唑类抑制剂的结构表征》，刊载于《国际分子科学杂志（Int J Mol Sci）》，2022年，第23卷。