Thiosemicarbazone and Semicarbazone Macrocyclic Chelators for Nuclear Imaging and Therapeutic Applications

Targeted alpha therapy has been demonstrated to be a promising method of treatment for metastatic cancer. A vital component of the radiopharmaceuticals employed in TAT is the development of chelators that effectively bind the radiometal under mild conditions. For effective use of these chelators, there must be a corresponding radionuclide that allows for radioimaging along with therapy. This thesis details the development of a group of macrocyclic chelators with thiosemicarbazone and semicarbazone pendant arms that were investigated with the therapeutic radionuclides 212Pb, 212Bi, 225Ac and 224Ra and imaging radionuclides 111In, 133La and 131Ba.