Green spectrophotometric analysis data for the assay of betrixaban and lercanidipine

Three facile, accurate, and eco-friendly spectrophotometric methods were developed for determination of the novel anticoagulant drug, betrixaban (BTX). The first method (method A) was based on the unique UV absorption spectrum of BTX, where direct analysis of BTX was performed at 229.4nm on the recorded zero order spectrum using methanol as the optimum solvent. While the second method(method B) was based on measuring difference absorption value(DA) of BTX at 335nm, which was obtained from pH-induced spectral difference (Difference spectra of BTX in 0.1M NaOH versus 0.1M HCl). The third mathematical spectrophotometric method (method C) was established for simultaneous analysis of BTX with the co-administered Ca channel blocker lercanidipine (LER). In this method, the first order derivative technique was utilized to resolve the overlapping UV spectra of both drugs. The first derivative amplitudes at 206nm and 229nm were used for quantitative assay of BTX and LER, respectively. All methods...