Transition-Metal-Catalyzed Hydrosulfoximination and Oxidation Reaction for the Synthesis of Sulfoximine Derivatives

We report herein a Au/Ag-cocatalyzed
chemoselective hydrosulfoximination reaction of simple ynamides with
free NH-sulfoximines, which produces the N-alkenylated sulfoximidoyl derivatives with quantitative
atom efficiency and good to excellent yields. Further elaborations
of the enamine isomers under Ru-catalyzed oxidative conditions to
cleave the CC double bonds can selectively afford urea-type
sulfoximines. The aforementioned catalytic reactions provide new opportunities
for the convergent and straightforward access to sulfoximine derivatives.