Bach2 represses effector programmes to stabilize Treg-mediated immune homeostasis

ChEBI2013-06-27 更新2026-07-21 收录

免疫稳态调控

Treg细胞功能

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Bach2 represses effector programmes to stabilize Treg-mediated immune homeostasis

创建时间：

2013-06-27

Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function

调节性T细胞功能

免疫稳态调控

Regulatory T (Treg) cells play central roles in maintaining immune homeostasis and self-tolerance. However, the molecular mechanisms underlying Treg cell homeostasis and suppressive function are still

NIAID Data Ecosystem80

Impact of Tcf1/Lef1 deficiency on Treg cells. Impact of Tcf1/Lef1 deficiency on Treg cells

Treg细胞功能

转录组比较

Comparison of transcriptome between control and Tcf1/Lef1-deficient Treg cells Overall design: Splenocytes were harvested from Foxp3-Cre+, Tcf1/Lef1 wild-type or double floxed mice (male and at 16 wee

NIAID Data Ecosystem60

Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients.

肿瘤免疫微环境

Treg细胞功能

Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated with local immunosuppression, which can be partly mediated by regulatory

NIAID Data Ecosystem40

Suppressor activity of Treg in R0 and R cultures a .

Treg细胞功能

细胞共培养

aThe data are means±SD of percent suppression measured in co-cultures of proliferating autologous responder cells with Treg generated in R0 or R cultures. R cultures were set up with 1 nM RAPA. Respon

NIAID Data Ecosystem60

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes hostâmicrobiota homeostasis

免疫稳态

Treg细胞功能

Foxp3+ regulatory T (Treg) cells are essential for immunological tolerance and homeostasis. In peripheral tissues, Treg cells acquire enhanced suppressive functions and co-opt distinct transcriptional

NIAID Data Ecosystem40

Bach2 represses effector programmes to stabilize Treg-mediated immune homeostasis

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