X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a sulfamide inhibitor GluGlu

X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a sulfamide inhibitor GluGlu Descriptor: (2~{S})-2-[[(2~{S})-1,5-bis(oxidanyl)-1,5-bis(oxidanylidene)pentan-2-yl]sulfamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Barinka, C, Shukla, S, Motlova, L. Deposit date: 2019-08-05 Release date: 2020-08-26 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors. J.Chem.Inf.Model., 2024

人类谷氨酸羧肽酶II（human glutamate carboxypeptidase II, GCPII）的X射线晶体结构：其E424M失活突变体与磺酰胺类抑制剂GluGlu形成的复合物。组分描述：(2S)-2-[[(2S)-1,5-二羟基-1,5-二氧代戊烷-2-基]磺酰胺基]戊二酸、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖…… 作者：Barinka C、Shukla S、Motlova L。提交日期：2019年8月5日；发布日期：2020年8月26日；最后修改日期：2024年11月13日。实验方法：X射线衍射（分辨率1.58 Å）。引用文献：《磺酰胺类双金属肽酶抑制剂的结构、生化与计算表征》，J.Chem.Inf.Model., 2024